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    Slco5a1 solute carrier organic anion transporter family, member 5A1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312907, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Slco5a1provided by RGD
    Official Full Name
    solute carrier organic anion transporter family, member 5A1provided by RGD
    Primary source
    RGD:1307132
    See related
    Ensembl:ENSRNOG00000008966 AllianceGenome:RGD:1307132
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLCO5A1 (solute carrier organic anion transporter family member 5A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 107.6), Heart (RPKM 60.5) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (11012001..11141180)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (6228938..6358124)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (5866362..5994748)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene PR/SET domain 14 Neighboring gene U6 spliceosomal RNA Neighboring gene sulfatase 1 Neighboring gene uncharacterized LOC120102810 Neighboring gene ATPase H+ transporting V1 subunit E1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue. Kindla J, et al. Cancer Biol Ther, 2011 Mar 15. PMID 21278488
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family member 5A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107898.1 → NP_001101368.1  solute carrier organic anion transporter family member 5A1

      See identical proteins and their annotated locations for NP_001101368.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473984
      UniProtKB/TrEMBL
      A0A8I6A406, A6JFD8
      Related
      ENSRNOP00000082764.1, ENSRNOT00000113639.1
      Conserved Domains (3) summary
      cd06174
      Location:134 → 532
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:544 → 598
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:132 → 727
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      11012001..11141180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109745.2 → XP_038965673.1  solute carrier organic anion transporter family member 5A1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A406
      Conserved Domains (1) summary
      cd17404
      Location:131 → 621
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    2. XM_008763495.4 → XP_008761717.1  solute carrier organic anion transporter family member 5A1 isoform X1

      See identical proteins and their annotated locations for XP_008761717.1

      UniProtKB/TrEMBL
      A0A8I6A406, D3ZZM7
      Related
      ENSRNOP00000011940.5
      Conserved Domains (1) summary
      cd17404
      Location:131 → 676
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    3. XM_039109744.2 → XP_038965672.1  solute carrier organic anion transporter family member 5A1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A406, D3ZZM7
      Conserved Domains (1) summary
      cd17404
      Location:131 → 676
      MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

    4. XM_039109746.1 → XP_038965674.1  solute carrier organic anion transporter family member 5A1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:21 → 264
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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